I’m looking forward to seeing the book in due course
This is a ‘must post’, I think.
My sister, Cynthia Jefferies, has been a successful children’s author for some time; now, heading in a slightly different direction, she is about to publish her first book for adults. It’s an historical novel, The Outrageous Fortune of Abel Morgan, set in the period after the Civil War. Cindy provides some background in a post on The History Girls blog – you might like to swing by and read what she has to say.
I’m looking forward to seeing the book in due course, meanwhile I wish her every success with the launch.
And ‘going out on a limb’? You’ll need to check out those History Girls to find out what that refers to.
Imagine an RNA molecule that can replicate … this is already quite life-like.
I have a really exciting story for you today, especially if you are interested in the origin of life and evolution.
A recent article in the magazine Science reports that Thomas Carell, a chemist at Ludwig Maximilian University in Munich, Germany, has outlined a process that can generate all four of the building blocks of RNA from compounds and conditions present on the pre-biotic Earth.
Why is this significant?
To understand, we need to grasp the importance of RNA. Its cousin, DNA, is the molecule used by most living things on Earth to store the genetic information that controls their form and function. RNA is also capable of storing genetic information, and some viruses use it in exactly this way. RNA is also essential in all living forms because it acts as a go between in the production of proteins from the DNA genetic material. RNA is less stable than DNA and copying errors are more likely. For this reason, DNA is a better long-term genetic store than RNA, but RNA is more dynamic. Think in terms of DNA as a library of printed recipe books, while RNA is like hand-copied notes on scraps of paper that enable the recipes to be taken to the kitchen.
But RNA has additional tricks up its sleeve. Not only can this molecule store genetic information, it can also catalyse biochemical reactions, including the synthesis of simple proteins. RNA is a bit of an all-rounder, and it’s not so hard to imagine that quite soon after being randomly synthesised by Carell’s process, RNA molecules might be formed as the dissolved RNA bases came into contact with tiny rock templates that could act to stabilise the process.
RNA also has the potential to self-replicate. Imagine an RNA molecule that can replicate (albeit with occasional errors). This is already quite life-like. Now image the population growing in places where the Carell process was providing reliable supplies of the four bases. Some of those RNA molecules will have errors, sooner or later an error, or a combination of errors will provide a version that replicates more efficiently, or gets trapped inside a lipid membrane that protects it from breakdown, or catalyses the production of a protein that makes the RNA more efficient in some way. If all of those things happen you have something that might be regarded as an early living form – an enclosed lipid membrane with a self-replicating genetic system that can mutate and evolve. Nothing more than that would be needed to kick of an expanding array of related forms.
The story as I describe it here is not complete and likely incorrect in many ways. I accept that. But though it’s a simplistic view, it’s also likely to be broadly correct as a bare outline. Over the next few years and decades I expect much more detail will become clear, especially detail about what is or is not possible. And I expect to see many of the steps to be experimentally demonstrated. Watch this space…
We were constantly surprised by the next unexpected vista
Every summer we go away somewhere different for a week – Donna and me along with two daughters, their husbands, and our four grandchildren. This year we stayed in a ski chalet in Haute-Nendaz in western Switzerland, just over the border from France.
Although prices are high in Switzerland, there are many wonderful compensations in terms of mountain scenery, clean streets and clean air, friendly people, and the walks. I had expected walks with big and tiring changes in elevation – and we certainly did our share of walks of that sort. But the bisses: what a wonderful experience!
I must admit, I had no idea what a bisse was when we drove from Geneva Airport, around Lake Geneva, and then south-west to Nendaz. I hadn’t even come across the word ‘bisse’. But we soon found a leaflet of local walks and discovered that several of them followed the local bisses. A bisse is an irrigation stream running gently downhill, almost following the contours of the mountains and hills. As a result the bisse paths are gentle and easy walking for the most part, and they wind around the slopes through woodland and meadow. The views of the mountains and valleys are spectacular; following the path through woodland and then coming out into the open again we were constantly surprised by the next unexpected vista.
All the way, the path is accompanied by the sparkling water hurrying down its channel, sometimes shallow, sometimes deep, and sometimes disappearing into a large pipe and reappearing beside the path again a little further on. Some of these paths follow one bisse gently uphill and then pick up a different one for the return, making a lovely, circular tour through the countryside.
A private railway built to transport coal from the local pits…
Visiting my daughter and her family in York recently, we walked near Aberford just outside Leeds. This was my son-in-law’s suggestion, he does a lot of walking and is interested in wildlife, footpaths, history, good walks and a whole lot more. Parking in Aberford, we followed a bridleway west along the bed of an old railway line.
The Fly Line was a private railway built to transport coal from the local pits to the nearby Leeds and Selby Railway Apart from the removal of the tracks, the old line is remarkably well preserved. We walked under the bridge shown in the photo above, and through a rather muddy tunnel. The Ordnance Survey One Inch map for 1885-1900 shows the line (marked as a mineral line) and the Six Inch map for 1842 to 1952 shows it in more detail, as well as the the coal pits along the line. But it fell out of use in 1924 and is not seen on later maps. The line passes through delightful woodland and I’d recommend it as an easy and enjoyable walk for anyone.
The railway was built by the Gascoigne family who also owned the coal mines and lived in the nearby Parlington Hall. (There’s more detail about Parlington Hall and its railway on a dedicated website.) Most of the old house has been demolished, and although we didn’t visit the remaining wing, we did get a distant view of the triumphal arch, built to commemorate the American victory in the War of Independence.
Along the way we came across a great example of two (or possibly three) trees, cross grafted as saplings. Someone had clearly tied them together tightly, possibly after removing a slice from each and lining up the cambial zones carefully so that they would heal and grow as one. That must have been decades ago and the result today is most striking.
On the whole, a fine day out and a great way to break our journey back to Cirencester from York.
The centre of Cirencester has buildings of a variety of ages, from the Roman City Wall (a small part of which is visible in the Abbey Park) to Victorian and more recent constructions. Walking in the town with my camera today, I took some shots of a 19th century development.
These are the upper floors of a three-storey terrace, a planned development that replaced older properties. The section at the right hand end was used as a florist’s shop for many decades (now Vodafone). I remember it as a child because my father was one of four brothers who owned and ran the shop as part of a larger business with several plant nurseries in the country areas around the town.
The shop had a wonderful cellar, always full of mysterious packages of garden chemicals and other shop stock, and before Christmas there were sometimes hyacinth bulbs being forced for early flowering. There was a marvellous fusty, moist, florist’s aroma in the cellar, but the most exciting thing was the knowledge that the cellar was bigger than the shop floor above. Castle Street was widened when the new development was built, but the cellars of the old buildings were retained. There are stone pillars in the cellar that support the heavy masonry above.
Here’s another view of the same shop from a different angle, the photo was taken by my father in the 1960s. I love the fact that this image includes the shop window displays as these always fascinated me as a young child. I also remember that my grandfather’s office window was above the main door on the corner, and the landscape design office was on the top floor with the small bay window.
And finally, for comparison, here’s another view of the same shop today.
Until those doors are in place neither the kitchen/diner extension nor the bedroom extension can receive their floor screeds…
Our builders have done much of the work that remains, but we’re waiting for our bi-fold and sliding doors to be fitted by the supplier. Until those doors are in place neither the kitchen/diner extension nor the bedroom extension can receive their floor screeds, and those will need a long time to dry out before floor tiles and wood flooring can be laid. For the same reason our new kitchen can’t be fitted – it’s stacked in boxes in the lounge.
We feel badly let down – not by our builder, Jack, and his team – they have done a grand job, but by the door suppliers. Those doors were ordered before Christmas! And the knock-on effects don’t stop there; because the lounge is full of kitchen units, we can’t unload the bulk of our furniture from the steel container parked on our drive. And the boxes containing summer clothes, paperwork, crockery, cutlery etc are blocked in by the furniture we can’t yet unload. Argghhh!
Ah well, it’s summer time. Now, where did I put those summer clothes? Oh… Wait a mo…
Meanwhile, here’s a view of the kitchen/dining extension. You’re looking in through bi-folds that are not yet there, and the opening on the right is also filled with bi-folds that are not yet there. Ho-hum.
I posted this on Facebook a few moments ago. I thought I’d pop it on the blog as well.
I’m still not sure what to do about Facebook. I’ve been thinking hard about binning my account altogether. I only visit two or three times a month these days, and most of my friends have my email address.
Possibly, I’ll post material to my blog instead (scilla.org.uk), it’s been rather neglected for the last few years, but I could use it for more frequent and spontaneous messages as well as longer articles.
But before I make any definite decisions, I’d like some feedback from anyone who might read this Facebook post. What do you think?
We need leaders who will stand up for common sense and rescue us from the mess we find ourselves in.
I cannot remain silent as I continue to watch this nation destroy itself. Our government is leading us into poverty in so many ways. Poverty economically as we lurch towards a self-harm Brexit because it’s the will of slightly more than half those who voted in the referendum; poverty in terms of our moral standards (look no further than Home Office actions against so many British citizens who cannot prove their citizenship); poverty in terms of health care as our hospitals crumble and fail under unsustainable budget cuts and shortage of staff; the grinding poverty of families, children and the elderly alike shorn of the state benefits they need and now dependent on food banks; the poverty of those working hard but still unable to rent or buy a decent home; and the poverty of unruly children in schools unable to provide an adequate education on shrinking budgets.
At the heart of all these failures is a government that isn’t governing properly. We need leaders who will stand up for common sense and rescue us from the mess we find ourselves in. I will vote for any candidate or any party that stands up and speaks the truth about the current situation and is brave enough to chart a route out of it. I will vote for kindness, truth, and generosity. I will not vote for thoughtlessness, falsehood or mean-mindedness.
Let’s rescue Britain and let’s do it now – before it’s too late. Use your vote and your voice to #RescueBritain. Vote in every local or national election, write to your MP, write to anyone with influence. Create a real stir, we need to hear everyone’s voice, the voice of the people. Whatever you write or say, tag it #RescueBritain – do it now!
Work is well under way now and we are close to moving back in.
I thought it was time to share something about our house project. In April 2018 we moved from St Neots to Cirencester, selling our 4-bedroom 1950 home where we’d lived since 1998, and buying a little 1960s home as a replacement.
We already had some ideas about the changes we might make, so soon after moving in we searched for an architect. We found Rural Workshop online and invited Tim Francis to visit us and talk about some possibilities. We were impressed by his ideas, flair for design and clear explanations so we asked him to go ahead and draw up plans for us. Tim made it easy for us by arranging the planning permissions for us; we have ended up with planning consent for an en suite bedroom as a side extension with a sympathetically designed pitched roof, and a flat-roofed rear extension to contain our new kitchen and dining space. Both new rooms will open onto a patio connecting the house with the main part of the back garden.
Plans in hand, we started looking for a builder who would be able to turn the design into a well-finished structure and renovate the old part of the house at the same time. It needs rewiring, replumbing, and generally updating, repairing and refinishing. We found Jack Rzasa in the nearby town of Cheltenham and decided that his team management skills and ‘get it done’ attitude were exactly what we needed. Work is well under way now and we are close to moving back in after four weeks out while the dusty and messy tasks of rewiring, knocking through and plastering are completed. We’re delighted with progress so far.